Greece’s economic recession and Common Agricultural Policy (CAP) reform are expected to affect farmers’ decision-making in terms of crop production, as well as to reduce the viability prospects of their agricultural holdings. Consequently, the development of a policy analysis tool for the Greek agriculture that will simulate the decision-making process of farmers under the changing institutional context is considered essential. The policy analysis tool could be used for the configuration of CAP, but also in its implementation and specification at local and national level. In the context of this research, data from the database of Agricultural University of Athens and Farm Accountancy Data Network (FADN) will be combined, in order to develop a sequential mathematical programming model. This model will take into account, on the one hand, the risk factor due to price and yield variation, and the constantly changing economic and agro-climatic conditions, on the other. The sequential character of the model will be parametrized appropriately according to foresight scenarios for price and yield variation in the context of the Fifth Assessment Report of the Intergovernmental Panel on Climate Change-IPCC. Thus, the aim of this research proposal is the development of a robust tool for farm decision-making simulation that will provide results in various geographic scales, from local to national level, and under different scenarios of future changes, and will be useful for the policy analysts and makers since it can support their decision-making on a scientifically sound basis. This research is co-financed by Greece and the European Union (European Social Fund-ESF) through the Operational Programme “Human Resources Development, Education and Lifelong Learning” in the context of the project “Strengthening Human Resources Research Potential via Doctorate Research” (MIS-5000432), implemented by the State Scholarships Foundation (ΙΚΥ).